Zoloft and Adderall: can they be taken together? (2023)

Zoloft and Adderall are stimulants used to help people with attention and concentration problems. They can also be effective in people with anxiety and depression. Although these drugs work differently, they are often prescribed together. Here are some facts about these drugs. The best way to take them is by following your doctor's instructions.

Always follow your doctor's instructions. This article is for informational purposes only. The same applies to oursAdderall-like over-the-counter stimulantseThe best sites on nootropic supplements.


  • 1 Zoloft at night Adderall in the morning
  • 2 Experience Adderall and Zoloft
  • 3 Weight Loss with Zoloft and Adderall
  • 4 Zoloft and Adderall ADHD
  • 5 Sertraline and Adderall combined
  • 6 Zoloft and Adderall Tired
  • 7 Can you take Adderall with antidepressants?
  • 8 Can you take Zoloft and Adderall at the same time?

Zoloft at night Adderall in the morning

Taking two doses of a drug at the same time is dangerous because it can cause serious side effects. It is best to take only one dose at a time. Your doctor will determine the dosage that is right for you based on your specific condition and health concerns. Zoloft is available in pills ranging from 25 to 100 mg. If you prefer to take it orally, you can mix the medication with 4 ounces of water.

(Video) Antidepressant & Stimulant Side Effects Often Labeled as Psychotic & Bipolar: Dr. Peter Gotzsche

Experience Adderall and Zoloft

If you've ever taken Adderall and Zoloft, you know that the combination can be very addictive. The two drugs share a similar chemical structure and can cause severe withdrawal symptoms, and you need to make sure you understand how they interact before you start using them together. Zoloft is a prescription drug that's commonly used to treat depression and other mood disorders, as well as social anxiety and panic disorder.

While Adderall and recreational antidepressants can be dangerous, doctors generally recommend that you take them as directed by your doctor. These drugs work by changing the chemistry of the brain. They affect serotonin levels, which are responsible for happiness, and norepinephrine levels, which control energy levels. Both drugs can make you drowsy and irritable, and they can have other negative effects as well.

Adderall and Zoloft can have side effects similar to Lexapro. Common side effects include loss of appetite, sweating, indigestion, and decreased sleep. Some people also experience increased muscle movement, increased urination, and increased sweating.

Zoloft and Adderall weight loss

Weight gain from Zoloft and Adderall can be prevented with proper diet and exercise. These drugs are used to treat major depressive disorders, anxiety disorders, social anxiety disorders, panic attacks, post-traumatic stress disorder, and premenstrual dysphoria. They work by increasing levels of serotonin in the brain, thereby improving mood. Unfortunately, many people gain weight while taking these drugs.

Choosing the right medication depends on the type of treatment, your insurance coverage, and how your body responds to the medication. Trying several different medications can help you find the one that works for you. However, it is important to remember that the FDA only approves these drugs for certain medical conditions, and some people may experience side effects while using them. Therefore, it's important to talk to your doctor and make sure you understand all of the risks and benefits before starting any new medication.

(Video) Antidepressant & Adderall Two Month Update (Treating Depression, Anxiety & ADHD)

While both drugs can cause weight loss, the potential for side effects is greater. Zoloft has addictive potential and can also lead to serious side effects such as depression. If you are concerned about losing weight after starting Zoloft, consider trying other antidepressants first.

Zoloft and Adderall ADHD

Taking antidepressants and stimulants for ADHD can be effective, but you need to be aware of drug interactions. Both can have harmful side effects. A combination of both can increase the risk of serotonin syndrome, which can have serious consequences. If you are taking both medicines, your doctor will carefully adjust your dose. It is also possible to abuse antidepressants and stimulants recreationally.

Related article:ADHD Natural Dietary Supplements for Adults

The choice of which medication to take depends on your health plan, personal preferences, and the severity of the symptoms. There are many options for treating ADHD, and a doctor can prescribe the right one for you. Zoloft and Adderall are two options. Both are effective in improving alertness and reducing impulsive behavior. Both drugs are approved by the Food and Drug Administration (FDA) for certain medical conditions. However, Adderall is sometimes used for unauthorized reasons.

Fortunately, Adderall is generally safe for long-term use at recommended dosages. While there may be some side effects initially, these will likely subside as your child becomes accustomed to the drug.

(Video) Adderall & Zoloft (UPDATE)

Sertraline and Adderall combined

Zoloft and Adderall are often prescribed together to treat depression and ADHD. Both drugs are stimulants and are thought to help people with depression and ADHD focus and complete tasks. However, using Adderall and Zoloft together can cause a condition called serotonin syndrome. It is important to discuss side effects with your doctor before starting treatment with any of the medications.

Adderall is FDA approved for the treatment of Attention Deficit Hyperactivity Disorder and Narcolepsy. It also helps reduce daytime sleepiness in people with narcolepsy. While not an antidepressant, doctors may prescribe Adderall for other conditions.

Sertraline and Adderall are not suitable for all patients. Some people can experience serious side effects, so the doctor may need to adjust the dosage of the two drugs to ensure the patient experiences the desired effects. Sertraline is also known to interact with other medications, medical conditions, and foods and beverages. Serious interactions can cause coma or death. Other side effects of taking sertraline and adderall together include nervousness and racing thoughts. It's also important to discuss any pre-existing medical conditions with a doctor before starting any new medication.

Tired of Zoloft and Adderall

Zoloft and Adderall are antidepressants, both of which can have side effects. Both drugs can cause extreme fatigue and depression. They can also increase the risk of suicidal thoughts. If you or a loved one get these side effects, see a doctor right away.

Both antidepressants and stimulants affect brain chemistry, which controls energy levels, sleep patterns, and mood. They are typically prescribed to treat major depressive disorder or attention deficit hyperactivity disorder. However, the combination of antidepressants and stimulants can lead to addiction.

(Video) Lexapro and Adderall for Anxiety & Depression! My Experience!

If you or a loved one are taking Zoloft, tell your doctor about any other medications you are taking. It's also important to disclose any dietary supplements you take. Although there are some interactions between these drugs, you should not take any other drugs unless you are absolutely sure that they do not affect each other.

Can you take Adderall with antidepressants?

There are several drugs that can interact with Adderall, but the combination can be safe. If you use an antidepressant like Xanax, consult your doctor before taking Adderall. You should not take too much of one or you will get side effects from the other.

You should start with a low Adderall dose and increase it each week. However, never take two doses at the same time. The recommended dosage of Adderall is ten milligrams once a day, but you can increase this over time as needed. Make sure you keep a list of all other medications you're taking and don't start any new ones without first talking to your doctor.

Adderall is an amphetamine-based stimulant commonly prescribed to treat ADHD. It is also sometimes used to treat narcolepsy. It is not recommended to take Adderall to ward off fatigue as it can lead to addiction. Therefore, Adderall withdrawal must be closely monitored by a doctor.

Can you take Zoloft and Adderall at the same time?

It is possible to take Adderall and Zoloft at the same time if you are suffering from depression, but you should always consult a doctor first. This will ensure you are getting the best treatment for your condition and help you avoid the potential side effects of any of these side effects.

(Video) Scared of Taking Zoloft? My Experience with Antidepressants

If you are taking an MAOI antidepressant, you should stop taking it before taking Adderall. Because they can interfere with each other's effects, which can lead to an increased risk of side effects and complications. Depending on which drug you are taking, there are also different interactions between the two drugs.

Antidepressants are prescription drugs that change brain chemistry. They affect energy levels, sleep patterns, and mood. Many people take them for depression. Adderall contains dextroamphetamine and amphetamine, which are important chemical messengers in the brain. While they are effective in treating depression, they also increase the risk of addiction.

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Zoloft and Adderall: can they be taken together? ›

Zoloft, or sertraline, and Adderall® generally cause serious interactions when used at the same time. Zoloft can increase the effects of Adderall® and trigger side effects the same as or similar to other antidepressants.

Can I take Zoloft at night and Adderall in the morning? ›

To keep you safe, your doctor will probably advise sticking with a low dose of antidepressants while taking Adderall. Your doctor might also advise that you space out your medications. If you take your antidepressant before bed, you can take your Adderall in the morning.

Is it safe to take ADHD medication with Zoloft? ›

Combining these medications can also increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle ...

What happens if you take Adderall and antidepressants together? ›

Concurrent use of stimulants with antidepressants is a high-risk behavior and is medically contraindicated9 due to potential cytochrome P450 2D6 (CYP2D6) enzyme inhibition and a resulting increase in serotonin levels.

What anxiety meds can be taken with Adderall? ›

Xanax is a benzodiazepine, while Adderall is a stimulant. Under the supervision of a doctor, the drugs may be safe to use together. Benzodiazepines slow down activity in the central nervous system and can help a person feel more relaxed and less anxious.

Is Zoloft and Adderall okay? ›

Zoloft and Adderall®

Zoloft, or sertraline, and Adderall® generally cause serious interactions when used at the same time. Zoloft can increase the effects of Adderall® and trigger side effects the same as or similar to other antidepressants.

Does Zoloft help you focus? ›

After you start taking sertraline, you may notice that your sleep, ability to concentrate on specific tasks and appetite improve before your mood. Make sure to keep using sertraline, even if you don't notice any immediate changes.

Can ADHD meds and antidepressants be taken at the same time? ›

A number of studies have shown that stimulants and nonstimulants do not have an interaction effect with SSRIs, so patients with ADHD and depression can generally take these medications simultaneously without any contraindication.

What drugs Cannot be taken with Zoloft? ›

Do not use sertraline with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).

Is Zoloft better than Adderall? ›

Adderall has an average rating of 7.4 out of 10 from a total of 466 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 17% reported a negative effect. Zoloft has an average rating of 7.2 out of 10 from a total of 1883 ratings on Drugs.com.

What not to mix with Adderall? ›

Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

What is the best antidepressant for ADHD? ›

These are often the first choice for ADHD, and they tend to work the best. Usually, you start at a low dose.
Your doctor may suggest one of four types:
  • Bupropion (Wellbutrin)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants like desipramine (Norpramin) and imipramine (Tofranil)
  • Venlafaxine (Effexor)
Apr 6, 2023

Can you take serotonin and Adderall together? ›

However, taking any type of medication that will change your serotonin levels along with Adderall, is particularly dangerous, as it may result in serotonin syndrome 2.This occurs when you take monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), or serotonin-norepinephrine reuptake ...

Why do I feel calm on Adderall? ›

Adderall is a stimulant that boosts your levels of serotonin, norepinephrine, and dopamine. These are neurotransmitters in your brain that calm and relax you so you can focus better.

Does Zoloft give you energy? ›

Once you've been taking Zoloft for long enough to feel its effects, you should start to experience feelings of relief, relaxation, and calm as the weight of your anxiety begins to lift. Some other changes that you might notice are an increase in your energy levels and appetite.

Is it better to take Zoloft at night or in the morning? ›

Zoloft is an SSRI that treats depression and other mental health conditions. It's usually taken once a day at any time during the day. But if it makes you tired, take it in the evening. If it makes you feel more awake, take it in the morning.

Does Zoloft make it hard to concentrate? ›

Though rare, Zoloft can cause more serious side effects, including: Low sodium blood levels: Symptoms of low sodium levels can include headache, weakness, or difficulty concentrating or remembering.

Does Zoloft calm the mind? ›

Zoloft is an antidepressant and is commonly prescribed for the treatment of depression, but it can also be used to relieve symptoms of anxiety as well.

Does Zoloft stop racing thoughts? ›

Zoloft (sertraline) "Zoloft has changed my life. I used to feel like I wanted to stop living. I had anxiety with racing thoughts, feeling short of breath, social anxiety, and obsessive bad thoughts. I no longer feel suicidal and my irritability has gotten 100% better.

What is the best ADHD medication for motivation? ›

Ritalin in the brain

Ritalin works by increasing the amount of dopamine released in the striatum, a key region in the brain related to motivation, action and cognition.

Can you be on ADHD meds and anxiety meds? ›

While both conditions can disrupt a person's quality of life, one condition may also worsen the other. Different treatments, such as prescription medications and psychosocial therapies, may help a person manage both conditions. Moreover, adults with ADHD and anxiety may benefit from combining these treatments.

What happens when you treat ADHD with antidepressants? ›

Abstract. Antidepressants differ in their effectiveness for treating attention-deficit/hyperactivity disorder (ADHD) in adults and children. None are as effective as psychostimulants for treating the attentional and cognitive symptoms, but they can help reduce impulsive and hyperactive behavior.

What reacts badly with Zoloft? ›

The bottom line. The antidepressant sertraline interacts with blood thinners and medications that raise serotonin levels. It also interacts with phenytoin, medications that affect heart rhythm, and alcohol.

Why is it better to take Zoloft at night? ›

You can take it either in the morning or evening, depending on your lifestyle and any side effects you experience. For example, if sertraline makes you drowsy, taking it at night might be your best choice. It's important that you establish a set time to take this medication every day and follow that schedule.

What works well with Zoloft for anxiety? ›

Xanax and Zoloft can treat a variety of mental health concerns, including depression and anxiety. In some cases, these medications may be prescribed together.

What is the Mexican equivalent of Adderall? ›

Clobenzorex (Asenlix, Dinintel, Finedal, Rexigen) is a stimulant drug of the amphetamine chemical class used as an appetite suppressant. The drug is legally distributed in Mexico under the trade name Asenlix by Aventis.

Why is my Adderall not working anymore? ›

The body can develop Adderall tolerance. If you are using it for medical reasons, you may feel as though it has stopped working or become less effective after a period of time. This is perfectly normal. Usually, your doctor will evaluate the efficacy of your current dose and prescribe a tiny increase in dose if needed.

Does Zoloft give you dopamine or serotonin? ›

Zoloft is advertised as an agent that increases serotonin levels, which is specifically associated with happiness.

What medications make Adderall less effective? ›

Adderall has a serious interaction with drugs called monoamine oxidase inhibitors (MAOIs). These include MAOI antidepressants, and certain drugs for Parkinson's disease or infections.

What is a normal amount of Adderall to take? ›

Adderall dosage for both children and adults starts at a lower dose, usually 2.5 mg once daily for children and 5 mg once or twice daily for adults. Adderall XR dosage for children often starts at 10 mg daily and dosage for adults usually starts at 20 mg daily.

At what age should you stop taking Adderall? ›

Medications that are FDA-approved specifically for ADHD in adults are the stimulants Adderall XR, Concerta, Focalin XR, Vyvanse, and the nonstimulant Strattera. The approved maximum age for use of these medications varies from fifty-five to sixty-five.

What are the top 3 ADHD medications? ›

The most popular ADHD medications among ADDitude readers include (in alphabetical order): Adderall XR (amphetamine) Concerta (methylphenidate) Dexedrine (amphetamine)

What are the alternatives to Adderall for adults? ›

SHORT-ACTING STIMULANT ALTERNATIVES — Currently available short-acting stimulants that may be used as alternatives to Adderall include dexmethylphenidate (Focalin, and generics), methylphenidate (Ritalin, Methylin, and generics), and dextroamphetamine (Zenzedi, ProCentra, and generics); their onset of action occurs ...

What antidepressants are good for energy and motivation? ›

Prozac (fluoxetine) and Wellbutrin (bupropion) are examples of “energizing” antidepressants; whereas Paxil (paroxetine) and Celexa (citalopram) tend to be more sedating.

What vitamins to take with Adderall? ›

Magnesium, Zinc, and Iron for ADHD

All three of these minerals are important for regulating levels of neurotransmitters and other brain chemicals, such as melatonin.

Can you be on Adderall and mood stabilizers? ›

Adderall in combination with antidepressants or other mood-stabilizing agents may help improve energy, mood, and activity levels in people with very hard-to-treat depression.

Which antidepressant is best for fatigue? ›

Antidepressants often prescribed for chronic fatigue include:
  • Tricyclics: amitriptyline (Elavil), desipramine (Norpramin), notriptyline (Pamelor)
  • Selective serotonin reuptake inhibitors (SSRIs): citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft)

Does Adderall stop racing thoughts? ›

Attention deficit hyperactivity disorder

Medications used to treat ADHD, such as Adderall or Methylphenidate, can be prescribed to patients with ADHD to calm these racing thoughts, most commonly in the morning when people wake up but just as well in the evening before sleep.

Why do I get so angry on Adderall? ›

Adderall can cause irritability in some people, which usually means their dosage could be too high, or they might need to switch medications. This irritability is caused by fluctuations in the brain chemicals dopamine, norepinephrine, and serotonin. Adderall withdrawal can also cause irritability.

Will Adderall work if I'm tired? ›

Additionally, lack of sleep will affect stimulant medication efficacy. You won't get the full benefit from the medication because your tired brain is operating less than optimally before you take it. You will then perform worse at work (or school), especially on tasks that are tedious or that require complex thinking.

What is the number 1 drug for anxiety? ›

Benzodiazepines (also known as tranquilizers) are the most widely prescribed type of medication for anxiety. Drugs such as Xanax (alprazolam), Klonopin (clonazepam), Valium (diazepam), and Ativan (lorazepam) work quickly, typically bringing relief within 30 minutes to an hour.

What meds are best for crippling anxiety? ›

SSRIs and SNRIs are often the first-line treatment for anxiety. Common SSRI brands are Celexa, Lexapro, Luvox, Paxil, and Zoloft. Common SNRI brands are Pristiq, Cymbalta, and Effexor XR. Pros: They are effective for a lot of people and they have a solid safety profile.

What is the best drug combination for anxiety? ›

Sometimes, combining one or more medications to treat anxiety and depression is best. A doctor may prescribe the following medications in addition to an SSRI or SNRI or use them on their own.
Examples include:
  • alprazolam (Xanax)
  • clonazepam (Klonopin)
  • diazepam (Valium)
  • lorazepam (Ativan)
Aug 30, 2022

Can you take Wellbutrin and Zoloft at the same time of day? ›

Combining Wellbutrin and Zoloft can help provide a broader spectrum of antidepressant benefits for many patients. Some patients report that when combining Wellbutrin and Zoloft, they experience improved moods and a sense of overall well-being in addition to increased energy levels.

How late in the morning can you take Adderall? ›

The first dose is usually taken when you wake up in the morning. If more doses are prescribed, take them as directed by your doctor, usually 4-6 hours apart. Taking this medication late in the day may cause trouble sleeping (insomnia). The dosage is based on your medical condition and response to treatment.

Why should you not take sertraline on a night? ›

You can feel drowsy in the first few days of taking sertraline. This should get better after the first week or two. If it makes you feel drowsy, try taking it just before you go to bed. You could also, strangely, get insomnia (difficulty getting to sleep), and disturbing dreams or nightmares.

Can you take ADHD medication and antidepressants? ›

Once a person's response to medication starts, it takes eight to 10 weeks to see the full benefit of an antidepressant. During this time, the standard medications for ADHD can be fine-tuned. These two classes of medications “play well with each other” and are commonly used together without interactions.

What should Zoloft not be mixed with? ›

Do not use sertraline with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).

What is the best combination of antidepressants? ›

Escitalopram and sertraline were found to have the best combination of efficacy and acceptability.

Does Zoloft increase dopamine? ›

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI), but, uniquely among most antidepressants, it shows relatively high (nanomolar) affinity for the DAT as well. As such, it has been suggested that clinically it may weakly inhibit the reuptake of dopamine, particularly at high dosages.

Is it OK to not take ADHD meds on weekends? ›

If you stop on the weekends, you basically start over on Monday,” he says. A person's body adjusts to the medication over the course of the first few months and side effects can lessen or disappear after that time.

Is it bad to take Adderall every day? ›

Long-term use of Adderall could lead to addiction, heart problems, slowed growth in children, or mental health issues.

What foods should you avoid while taking Adderall? ›

Foods that contain large amounts of citric acid and ascorbic acid (vitamin C) will prevent the absorption of both Adderall IR and XR into the body. Fruit juices high in vitamin C, soda drinks, and food with high levels of preservatives should be avoided an hour before and after taking Adderall.

Is 100 mg of Zoloft a lot? ›

The maximum Zoloft dosage for intermittent dosing is 100 mg per day.

What sleep aid can I take with Zoloft? ›

Yes, you can use melatonin and Zoloft together. Zoloft (sertraline) and other SSRIs can cause insomnia, which means it wouldn't be unusual for people prescribed Zoloft to consider sleep aids such as melatonin.

What is the best antidepressant for ADHD and anxiety? ›

Your doctor may suggest one of four types:
  • Bupropion (Wellbutrin)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants like desipramine (Norpramin) and imipramine (Tofranil)
  • Venlafaxine (Effexor)
Apr 6, 2023


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